Combination is used for pain relief and fever. It is used in rheumatoid arthritis, osteoarthritis and menstrual pain to relieve pain and inflammation. It is also used to treat mild to moderate pain. It works by blocking the synthesis of prostaglandins that cause fever, pain and inflammation (redness and swelling).
Each 5 ml contains:
Paracetamol IP 250 mg
Mefenamic Acid IP 100 mg
Suspension
Antipyretic
Rheumatoid arthritis Osteoarthritis Dysmenorrhea Mild to moderate pain Inflammation Fever
Both compounds belong to non-steroidal anti-inflammatory drugs which inhibits cyclooxygenase. Paracetamol is a derivative of acetaminophen, or paracetamol, with the molecular formula glycine, N, N-diethyl-,4-(acetylamino)phenyl ester. Paracetamol is a weak inhibition of COX-1 and COX-2, further inhibiting prostaglandin synthesis. Mefenamic acid is an anthranilic acid derivative. It exhibits anti-inflammatory, analgesic, and antipyretic activities.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, bleeding/clotting problems, blood disorders (e.g., anemia), high blood pressure, diabetes, heart disease (e.g., history of heart attack), liver disease, growths in the nose (nasal polyps), obesity, tobacco use, history of stomach/intestine/esophagus problems (e.g., bleeding, ulcers, recurring heartburn), stroke, swelling of the ankles/feet/hands.
While generally well-tolerated, some individuals may experience side effects, including:
Nausea,
Diarrhea or constipation (less common with magaldrate than with other antacids),and
Stomach cramps.
Most side effects are mild and temporary. However, if you experience more severe reactions or if the side effects persist, it is important to contact a healthcare provider.